Clinical setup and evaluation of an in-line ion selective sensor in spent dialysate of patients with chronic kidney disease.
What you will do
Chronic kidney disease (CKD) affects about 10 percent of the population worldwide. While kidney transplantation remains the best treatment option, the lack of suitable organs makes that the majority of end stage renal disease (ESRD) patients is dependent upon lifestyle-limiting dialysis treatment. For this, patients must visit the hospital at multiple times per week (normally 3 times/week) and during the treatment a machine is connected to the blood system of the patient to remove waste, extra chemicals and fluid from the blood. The machine thus helps the body to keep electrolytes and fluid in balance in case the kidney is no longer able to perform these important functions. Information on electrolytes concentrations is currently only available before and/or after the dialysis treatment using regular blood sampling. At imec a revolutionary miniaturized sensor technology has been developed with built-in reference to enable continuous sensing without the need for recalibration. Using this sensor technology it becomes possible to obtain information of electrolyte concentrations during dialysis, thereby enabling an optimized, individualized dialysis treatment.
In this project, the student will apply the imec in-line ion-selective sensor platform in a clinical setting to compare measurements of Na+, K+, Ca2+, Cl- and pH with clinical chemistry lab gold standard methods. To this end the student will perform experiments to calibrate the in-line platform and will implement the measurement in a clinical research setting. The student will collect data during dialysis treatment and will compare the outcome from these measurements with gold standard clinical chemistry lab values. The student will write a report on the findings.
Main tasks for the student:
What we do for you
A recently published technology roadmap by the Kidney Health Initiative (KHI) aims to pave the road towards innovative renal replacement therapies, aiming to improve the quality of life of kidney patients.
We offer you the opportunity to be part of this international roadmap, and contribute to realizing relevant milestones that can help kidney patients. This project builds on expertise of imec’s Connected Health Solution (CHS) and Internet-of-Things (IoT) teams. Support in this project comes from a multi-disciplinary team with expertise from hardware design to algorithm development and with clinical partners.
Who you are
Click on ‘apply’ to submit your application. You will then be redirected to e-recruiting.
Please be advised that non-EU/EEA country students that are studying outside of the Netherlands, need to have a work-permit to be able to do an internship in the Netherlands.